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Generic Name: Danazol
Brand Names: Danocrine, Cyclomen

Danazol : Important Information

• Danazol (DA-na-zole) may be used for a number of different medical problems. These include treatment of:
  • Pain and/or infertility due to endometriosis;
  • A tendency for females to develop cysts in the breasts (fibrocystic breast disease); or
  • Hereditary angioedema, which causes swelling of the face, arms, legs, throat, windpipe, bowels, or sexual organs.
  • Danazol may also be used for other conditions as determined by your doctor.
  • This medicine is available only with your doctor's prescription, in the following dosage form:
  • Oral Capsules (U.S. and Canada)

What is Danazol?

• Danazol is a derivative of the synthetic steroid ethisterone, a modified testosterone.
• Danazol decreases the pituitary hormones FSH and LH and exerts an antiproliferative effect upon the endometrium, leading to amenorrhea. This effect is useful for patients with endometriosis.

What to discuss before using Danazol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Danazol, the following should be considered:

• Tell your doctor if you have ever had any unusual or allergic reaction to Danazol, androgens (male hormones), or anabolic steroids. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
• Danazol is not recommended for use during pregnancy, since it may cause a female baby to develop certain male characteristics.
• Breast-feeding-Breast-feeding is not recommended while you are taking this medicine because it may cause unwanted effects in the baby.
• Danazol may cause male-like changes in female children and cause premature sexual development in male children. It may also slow or stop growth in any child.
• Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of Danazol in the elderly with use in other age groups, Danazol has effects similar to androgens (male hormones). Androgens used in older males may increase the risk of developing prostate enlargement or cancer.
• Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking Danazol, it is especially important that your health care professional know if you are taking any of the following:
  • Anticoagulants (blood thinners)-Danazol may increase the effects of these medicines and possibly increase the risk of severe bleeding
  • Tacrolimus (e.g., Prograf)-Danazol may increase the effects of tacrolimus by increasing the amount of that medicine in the body
• Other medical problems-The presence of other medical problems may affect the use of Danazol. Make sure you tell your doctor if you have any other medical problems, especially:
  • Blood clotting disorders or
  • Severe liver disease or
  • Tumor caused by too much male hormones or
  • Tumor on the genitals or
  • Unusual bleeding from the vagina-Danazol should not be used when these conditions exist
  • Porphyria-This condition may be made worse
  • Type 2 diabetes mellitus-Danazol may increase blood glucose (sugar) levels
  • Epilepsy or
  • Heart disease or
  • Kidney disease or
  • Migraine headaches-These conditions can be made worse by the fluid retention (keeping too much body water) that can be caused by Danazol

Danazol Dosage Method

• The dose of Danazol will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Danazol. If your dose is different, do not change it unless your doctor tells you to do so. The number of capsules that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problems for which you are taking Danazol.
• Adults and teenagers:
  • For treatment of endometriosis: 100 to 400 milligrams (mg) two times a day for at least three to six months, and possibly for nine months.
  • For treatment of fibrocystic breast disease: 50 to 200 mg two times a day for six months or until signs of the disease go away, whichever comes first.
  • For prevention of attacks of hereditary angioedema: 200 mg two or three times a day. The dose may be lowered, depending upon your condition.
• Children: your doctor must determine the Danazol dosage.

Miss a dose: Problems?

• If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Danazol Overdose?

• If overdose is suspected, contact your local poison control center or emergency room immediately.

Avoid During Treatment

• Contact your doctor if you are a female and have a larger clitoris (sexual organ), deepening of your voice, or unnatural hair growth after taking Danazol. Your doctor may advise you to stop taking the medicine so these effects do not get worse.
• For patients with diabetes:
  • This medicine may affect blood glucose (sugar) levels. If you notice a change in the results of your blood or urine glucose test or if you have any questions about this, check with your doctor.
• Danazol may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness, or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine:
  • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
  • Wear protective clothing, including a hat. Also, wear sunglasses.
  • Apply a sun block product that has a skin protection factor (SPF) of a least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have questions about this, check with your health care professional.
  • Apply a sun block lipstick that has an SPF of at least 15 to protect your lips.
  • Do not use a sunlamp or tanning bed or booth.
• If you have a severe reaction from the sun, check with your doctor.
• If you are taking Danazol for endometriosis or fibrocystic breast disease :
  • During the time you are taking Danazol, your menstrual period may not be regular or you may not have a menstrual period at all. This is to be expected when you are taking this medicine. If regular menstruation does not begin within 60 to 90 days after you stop taking this medicine, check with your doctor.
  • During the time you are taking Danazol, you should use birth control methods that do not contain hormones. If you have any questions about this, check with your health cares professional.
  • If you suspect that you may have become pregnant, stop taking this medicine and check with your doctor. Continued use of Danazol during pregnancy may cause male-like changes in female babies.

Danazol Side Effects

Check with your doctor as soon as possible if any of the following side effects occur:

• Acne; dark-colored urine; increased oiliness of hair or skin; muscle cramps or spasms; swelling of feet or lower legs; unusual tiredness or weakness; weight gain (rapid)
• Bleeding gums; bloating, pain or tenderness of abdomen or stomach; blood in urine; burning, numbness, pain, or tingling in all fingers except the smallest finger; changes in vision; chest pain; chills; complete or partial numbness or weakness on one side of body; cough; coughing up blood; diarrhea; difficulty in speaking; difficulty in swallowing; discharge from nipple; eye pain; fast heartbeat; fever; headache; hives or other skin rash; joint pain; light-colored stools; loss of appetite (continuing); loss of muscle coordination; more frequent nosebleeds; muscle aches; nausea; purple- or red-colored, or other spots on body or inside the mouth or nose; restlessness; shortness of breath; sore throat; sweating; tingling, numbness, or weakness in legs, which may move upward to arms, trunk, or face; unusual bruising or bleeding; unusual tiredness, weakness, or general feeling of illness; vomiting; yellow eyes or skin.
• Decrease in breast size; irregular menstrual periods; weight gain
• Enlarged clitoris; hoarseness or deepening of voice; unnatural hair growth
• Changes in semen; decrease in size of testicles
• Other side effects may occur that usually do not need medical attention.These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
  • Flushing or redness of skin; mood or mental changes; nervousness
  • Increased sensitivity of skin to sunlight
  • Burning, dryness, or itching of vagina; vaginal bleeding
• Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

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