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Generic Name:folic acid
Brand Names:folic acid

Folic Acid: Important Information

  • Take this medication only under the supervision of your doctor.

What is Folic Acid

  • Folic acid is a naturally occurring substance that is important for the formation of red and white blood cells. Folic acid is present in foods such as dried beans, peas, lentils, oranges, whole-wheat products, liver, asparagus, beets, broccoli, brussels sprouts, and spinach.
  • As medication, folic acid is used to treat folic acid deficiency and megaloblastic anemia caused by folic acid deficiency.
  • Folic acid may also be used for purposes other than those listed in this medication guide.

What to Discuss Before Using Folic Acid

  • Folic acid should not be taken to treat undiagnosed anemia. Folic acid may hide the symptoms of pernicious anemia, leading to neurologic damage. Treatment of anemia during folic acid therapy may also require vitamin B12.
  • Folic acid is in the FDA pregnancy category A. This means that it is safe to take folic acid during pregnancy. In fact, increased amounts of folic acid are recommended during pregnancy to reduce the risk that folic acid deficiency will cause. Talk to your doctor about taking folic acid during pregnancy.
  • It is safe to use folic acid during breast-feeding. Talk to your doctor about taking this medication if you are breast-feeding a baby.

Folic Acid Dosage Method

  • Take folic acid exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, nurse or pharmacist to explain them to you.
  • Take each dose with a full glass of water.
  • Folic acid is usually taken every day. Follow your doctor's instructions.
  • Sometimes, it may be necessary to receive folic acid by injection.
  • Store folic acid at room temperature away from moisture and heat.

Miss a dose: Problems?

  • Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed, and take only your next regularly scheduled dose.
  • Do not take a double dose of this medication unless directed by your doctor.

Folic Acid Overdose?

  • A folic acid overdose is unlikely to threaten life. Call an emergency room or poison control center for advice.
  • Symptoms of folic acid overdose are not known.

Avoid During Treatment

  • There are no restrictions on food, beverages or activities while you are taking folic acid unless your doctor directs otherwise.

Folic Acid Side Effects

  • Side effects of folic acid are not common.
  • Stop taking folic acid and seek emergency medical treatment if you experience an allergic reaction (difficulty in breathing; closing of your throat; swelling of your lips, tongue or face; or hives).
  • Continue taking folic acid and talk to your doctor if you experience any of the following less serious side effects which have occurred with large doses of folic acid:
    • nausea
    • decreased appetite
    • abdominal distention
    • flatulence
    • bitter or bad taste
    • insomnia and
    • difficulty in concentration
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

  • Large doses of folic acid may decrease the effects of phenytoin (Dilantin). Your doctor may need to adjust your dose of phenytoin to prevent seizures during treatment with folic acid.
  • Drugs other than those listed here may also interact with folic acid. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.


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Folic acid is a B vitamin needed for cell replication and growth. Folic acid helps to form building blocks of DNA, the body’s genetic information, and building blocks of RNA, needed for protein synthesis in all cells. Therefore, rapidly growing tissues, such as those of a fetus, and rapidly regenerating cells, like red blood cells and immune cells, have a greater requirement of folic acid. Folic acid deficiency results in a form of anemia that responds quickly to folic acid supplementation.

Folic acid is needed by the body to utilize vitamin B12. Proteolytic enzymes inhibit folic acid absorption. People taking proteolytic enzymes are advised to supplement with folic acid. Folic acid is not generally associated with side effects. However, folic acid supplementation can interfere with the laboratory diagnosis of vitamin B12 deficiency, possibly allowing the deficiency to progress undetected to the point of irreversible nerve damage. Although vitamin B12 deficiency is uncommon, no one should supplement with 1,000 mcg or more of folic acid without consulting a doctor.

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