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Generic Name: ondansetron (injection) (on DAN se tron)
Brand Names: Zofran

Zofran (ondansetron) : Important Information

  • Before receiving Zofran injection, inform your doctor if you have liver disease, a personal or family history of Long QT syndrome, or if you have had an allergic reaction to any medicine similar to Zofran, including dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).
  • Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by Zofran injection.
  • Zofran (ondansetron) injection can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
  • Call your doctor at once if you have stiffness in your neck, or muscle spasms or twitching (especially in your face).
  • There may be other drugs that can affect Zofran (ondansetron) injection. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What is Zofran (ondansetron)

  • Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.
  • Zofran (ondansetron) injection is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy).
  • Zofran (ondansetron) injection may also be used for purposes other than those listed in this medication guide.

What to discuss before treatment

  • Before using Zofran injection, tell your doctor if you have:
    • liver disease;
    • a history of allergic reaction to any medicine similar to Zofran, including dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi); or
    • a personal or family history of Long QT syndrome.
  • If you have any of these conditions, you may not be able to use Zofran injection, or you may need a dosage adjustment or special tests during treatment.
  • FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
  • Zofran can pass into breast milk and may harm a nursing baby. Do not use this Zofran medication without informing your doctor if you are breast-feeding a baby.

Zofran Dosage Method

  • Zofran injection is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. In most cases, only one dose of Zofran injection is given just before the start of surgery or chemotherapy. Sometimes a second and third dose is also given at 4 hours and 8 hours after the first dose. The medicine must be given through an IV infusion, and can take up to 15 minutes to complete.
  • Zofran injection is not for preventing nausea or vomiting that are caused by factors other than chemotherapy or surgery.
  • If you receive this medicine at home and you keep your medicine there, store Zofran (ondansetron) injection at room temperature away from heat and light.

Miss a dose: Problems?

  • Call your doctor to discuss if you have missed a dose of Zofran.

Zofran Overdose?

  • Seek emergency medical attention if you think you have received too much of this Zofran medicine.
  • Symptoms of a Zofran overdose may include sudden loss of vision, severe constipation, feeling light-headed, fainting.

Avoid During Treatment

  • Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by Zofran injection.
  • Zofran (ondansetron) injection can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Zofran Side Effects

  • Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
  • Call your doctor at once if you have any of these serious side effects:
    • blurred vision or temporary blindness;
    • muscle spasm or twitching, especially in your face; or
    • stiffness in your neck.
  • Other less serious side effects are more likely to occur, such as:
    • diarrhea;
    • headache;
    • fever;
    • drowsiness;
    • blurred vision; or
    • pain or redness where the medicine is injected.
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

  • Before receiving Zofran injection, tell your doctor if you are using any of the following drugs:
    • phenytoin (Dilantin), phenobarbital (Luminal);
    • carbamazepine (Carbatrol, Tegretol);
    • tramadol (Ultram);
    • rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, Rifater);
    • amiodarone (Cordarone), mibefradil (Posicor);
    • cimetidine (Tagamet);
    • clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Ery-Tab); or
    • HIV medicines such as indinavir (Crixivan), saquinavir (Invirase), ritonavir (Norvir), or nelfinavir (Viracept).
  • If you are using any of these drugs, you may not be able to use Zofran (ondansetron) injection, or you may need dosage adjustments or special tests during treatment.
  • There may be other drugs not listed that can affect Zofran injection. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.


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Zofran injections are used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer. Zofran (ondansetron) injection blocks the actions of chemicals in the body that can trigger nausea and vomiting.  Zofran injection may cause serious side effects in some people, especially people who have heart or blood vessel disease. Be sure that you discuss with your doctor the risks of using Zofran injection medication as well as the good that it can do.

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