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Generic Name: pancrelipase (oral) (pan kree LYE pace)
Brand Names: Cotazym, Cotazym-S, Creon 10, Creon 20, Creon 5, Ilozyme, Ku-Zyme, Pancrease, Pancrease MT 10, Pancrease MT 16, Pancrease MT 20, Pancrease MT 4, Pancron D/ R, Ultrase, Ultrase MT 12, Ultrase MT 18, Ultrase MT 20, Viokase, Zymase

Cotazym : Important Information

• Take this medication exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you. Taking this medication properly is the most important factor in getting the maximum benefit of this medication.
• Do not inhale the powder inside the capsules or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.

What is Cotazym

• A combination of three enzymes (proteins): lipase, protease, and amylase. These enzymes are produced naturally in the pancreas and are important in the digestion of fats, proteins, and sugars.
• Used to replace these enzymes when the body does not have enough of its own. This medication reduces the pain associated with disorders of the pancreas. Conditions for which this medication may be used include cystic fibrosis, chronic inflammation of the pancreas, and blockage of the pancreatic ducts. In addition, it may be used following removal of the pancreas.

What to Discuss before Using

• Do not take this medication without first talking to your doctor if you:
  • are allergic to pork products
  • have acute pancreatitis
  • have an acute worsening of a chronic pancreatic disease
• You may not be able to take this medication or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.
• The Pancrease and Pancrease MT brands of pancrelipase are in the FDA pregnancy category B. This means that they are not expected to harm an unborn baby. Other brands are in the FDA pregnancy category C or are not assigned an FDA pregnancy category. This means that it is not known whether they will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.
• It is also not known whether this medication will harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding.

Cotazym Dosage Method

• Take exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
• Taking this medication properly is the most important factor in getting the maximum benefit of this medication.
• Taken before or during each meal or snack. Follow your doctor's specific instructions.
• Do not hold the tablets or capsule contents in your mouth. This may cause irritation of the inside of your mouth.
• Do not crush or chew the capsules or tablets. Swallow them whole. If swallowing is difficult, some formulations can be opened and sprinkled onto a soft food such as applesauce or pudding. The soft food should then be swallowed immediately without chewing and followed with a beverage to ensure swallowing. Ask your doctor about such formulations if you are having difficulty swallowing your pills.
• Do not inhale the powder inside the capsules or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.
• Do not change brands without first talking to your doctor or pharmacist. Some brands are interchangeable while others are not. Your doctor and/ or pharmacist know which brand/ generic formulations may be substituted for another.
• Store at room temperature away from moisture and heat.

Miss a dose: Problems?

Skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

Cotazym Overdose?

• Seek emergency medical attention.
• Symptoms of an overdose are not known but may include diarrhea and stomach upset.

Avoid During Treatment

Follow any special diet recommendations made by your doctor while taking pancrelipase.

Cotazym Side Effects

• Stop taking this medication and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).
• Other, less serious side effects may also occur. Continue to take this medication and notify your doctor if you experience:
  • nausea or vomiting
  • abdominal discomfort, pain, or cramping
  • diarrhea or constipation
  • greasy stools
  • perianal irritation
  • flatulence
  • irritation to the skin or lungs after coming in contact with capsule contents
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

This medication is not known to interact with any other medications. However, talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

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