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Generic Name: etidronate (eh TIH droe nate)
Brand Names: Didronel

Etidronate: Important Information

  • Take each dose with a full glass (6 to 8 ounces) of tap water or bottled water.
  • Do not eat any food, drink any liquid other than water, or take any medicines (including vitamins and antacids) for at least 2 hours before and 2 hours after a dose of this medication.

What is Etidronate

  • This medication alters the cycle of bone formation and breakdown in the body.
  • Used to treat Paget's disease, and to treat conditions of irregular bone growth due to hip fracture or spinal cord injury.

What to Discuss before Using

  • Do not take this medication without first talking to your doctor if you have:
    • diarrhea
    • a problem swallowing, such as a narrowing of the esophagus
    • a stomach or esophageal ulcer or disease
    • kidney disease
  • You may not be able to take this medication, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
  • This medication is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not take without first talking to your doctor if you are pregnant or could become pregnant during treatment.
  • It is not known whether this medication passes into breast milk. Do not take it without first talking to your doctor if you are breast-feeding a baby.

Etridonate Dosage Method

  • Take exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Take each dose with a full glass (6 to 8 ounces) of tap water or bottled water.
  • Do not eat any food, drink any liquid other than water, or take any medicines (including vitamins and antacids) for at least 2 hours before and 2 hours after a dose of etidronate.
  • Do not crush, chew, or suck the pills. Swallow them whole.
  • It is important to take regularly to get the most benefit.
  • Your doctor may want you to have blood tests or other medical evaluations during treatment to monitor progress and side effects.
  • Store at room temperature away from moisture and heat.

Miss a dose: Problems?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose.

Etridonate Overdose?

  • Seek emergency medical attention if an overdose is suspected.
  • Symptoms of an overdose are not known but nausea, heartburn, pain in the abdomen, diarrhea, muscle cramps, numbness or tingling, uncontrollable facial grimacing, seizures, irritability, and abnormal behavior may be expected to occur.

Avoid During Treatment

There are no restrictions on food, beverages, or activity while taking etidronate unless otherwise directed by your doctor

Etridonate Side Effects

  • Stop taking this medication and seek emergency medical attention or contact your doctor immediately if you experience any of the following serious side effects:
    • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
    • difficulty or pain when swallowing
    • pain or burning under the ribs or in the back
    • new or worsening heartburn
  • Other, less serious side effects may be more likely to occur. Continue to take this medication and talk to your doctor if you experience:
    • diarrhea
    • nausea
    • muscle or joint soreness or aches
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

  • Do not take any other medicine, including vitamins, minerals, or other supplements, within 2 hours before or 2 hours after a dose of this medication, unless otherwise directed by your doctor. Any drug that is taken within this time frame can decrease the effects of this medication.
  • Before begining treatment, tell your doctor if you are taking warfarin (Coumadin). You may require a dosage adjustment or special monitoring during treatment.
  • Drugs other than those listed here may also interact. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

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