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Generic Name: fenofibrate (fen oh FIH brate)
Brand Names: Antara, Lofibra, TriCor, Triglide

Fenofibrate : Important Information

  • Rarely, treatment with Fenofibrate has been associated with a serious side effect affecting the muscles. Contact your doctor immediately if you experience unusual or unexplained muscle pain, tenderness, or weakness especially if accompanied by fever or a "flulike" feeling.
  • Avoid alcohol or use it only in moderation. Alcohol can raise triglyceride levels, and it can be damaging to the liver while you are taking this medication.
  • Follow any special diet and exercise plan recommended by your doctor while taking this medication. Diet and exercise are important factors in controlling cholesterol.

What is Fenofibrate

  • A fibric acid derivative. This medication helps reduce types of fat in the blood. It is especially good at lowering triglycerides and a form of cholesterol called very-low-density lipoprotein (VLDL). High levels of these types of fat in the blood are associated with an increased chance of pancreatitis, an inflammation of the pancreas that can result in severe stomach pain and even death.
  • Used to reduce triglycerides and cholesterol in the blood.

What to Discuss before Using

  • Before taking fenofibrate, tell your doctor if you have
    • liver disease
    • biliary cirrhosis
    • kidney disease
    • gallbladder disease
    • hypothyroidism (an underactive thyroid gland)
    • diabetes
  • You may not be able to take this medication, or you may require a special dosage or monitoring during treatment if you have any of the conditions listed above.
  • In the FDA pregnancy category C. This means that it is not known whether this medication will be harmful to an unborn baby. Do not take without first talking to your doctor if you are pregnant or could become pregnant during treatment.
  • Should not be used by nursing mothers. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Fenofibrate Dosage Method

  • Take exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Take each dose with a full glass of water.
  • Can be taken with or without food.
  • It is important to take regularly to get the most benefit.
  • Your doctor may want you to have blood tests or other medical evaluations during treatment to monitor progress and side effects.
  • Store at room temperature away from moisture and heat.

Miss a dose: Problems?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication unless your doctor directs otherwise.

Fenofibrate Overdose?

  • Seek emergency medical attention if an overdose is suspected.
  • Symptoms of an overdose are not known.

Avoid During Treatment

  • Follow any diet or exercise plan outlined by your doctor. Diet and exercise are important factors in controlling cholesterol.
  • Avoid alcohol or use it only in moderation. Alcohol can raise triglyceride levels, and it can be damaging to the liver while you are taking this medication.

Fenofibrate Side Effects

  • Rarely, treatment with this medication has been associated with a serious side effect affecting the muscles. Contact your doctor immediately if you experience unusual or unexplained muscle pain, tenderness, or weakness especially if accompanied by fever or a "flulike" feeling.
  • If you experience any of the following serious side effects, stop taking this medication and contact your doctor or seek medical attention:
    • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
    • severe stomach pain, nausea, or vomiting
    • fever
  • Other, less serious side effects may be more likely to occur. Continue to take fenofibrate and talk to your doctor if you experience:
    • joint pain
    • indigestion
    • bloating or flatulence
    • a rash
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

  • Before taking this medication, talk to your doctor if you are taking any of the following medicines:
    • an anticoagulant (blood thinner) such as warfarin (Coumadin)
    • cyclosporine (Neoral, Sandimmune)
    • lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), atorvastatin (Lipitor), or cerivastatin (Baycol)
    • cholestyramine (Questran) or colestipol (Colestid)
  • You may not be able to take this medication, or you may require a special dosage or monitoring during treatment if you are taking any of the drugs listed above.
  • Drugs other than those listed here may also interact. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.


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