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Generic Name: cyclobenzaprine (sye kloe BEN za preen)
Brand Names: Flexeril
Flexeril : Important Information
- Do not stop taking this medication suddenly if you have been taking it regularly for more than 1 week. This may cause nausea, headache and general discomfort.
- Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Flexeril.
What is Flexeril
- A muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain.
- Used to relieve pain, tenderness, and limitation of motion caused by muscle spasms. It is used, along with rest and physical therapy, for short-term treatment (i.e., 2 to 3 weeks).
What to Discuss before Using
- Do not take cyclobenzaprine if you:
- have recently (within the last 6 weeks) had a heart attack
- have irregular heartbeats
- have a heart block
- have heart conduction disturbance
- have congestive heart failure
- have hyperthyroidism that is not under control
- Before taking this medication, tell your doctor if you have:
- urinary retention
- narrow-angle glaucoma or increased intraocular pressure (pressure inside the eye)
- You may need a lower dose or special monitoring during treatment if you have any of the conditions listed above.
- In the FDA pregnancy B. This means that it is unlikely to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.
- It is not known whether this medication passes into breast milk. Do not take without first talking to your doctor if you are breast-feeding a baby.
Flexeril Dosage Method
- Take exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
- Take each dose with a full glass of water.
- Usually taken several times a day. Follow your doctor's instructions.
- You should begin to notice relief from your symptoms after 1 to 2 days of treatment.
- Do not stop taking this medication suddenly if you have been taking it regularly for more than 1 week. Stopping suddenly may cause nausea, headache, and general discomfort.
- Store at room temperature away from moisture and heat.
Miss a dose: Problems?
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take your next regularly scheduled dose. Do not take a double dose of this medication.
Flexeril Overdose?
- Seek emergency medical attention.
- Symptoms of an overdose include drowsiness, seizures, irregular heartbeats, hallucinations, and difficulty breathing.
Avoid During Treatment
- Use caution when driving, operating machinery, or performing other hazardous activities. This medication may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
- Use alcohol cautiously. Alcohol may increase drowsiness and dizziness.
Flexeril Side Effects
- If you experience any of the following serious side effects, stop taking this medication and seek emergency medical attention:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives)
- seizures, hallucinations, or confusion
- blurred vision
- increased heart rate
- depression
- Other, less serious side effects may be more likely to occur. Continue to take this medication and talk to your doctor if you experience:
- drowsiness or dizziness
- dry mouth or a bad taste in your mouth
- insomnia
- difficulty urinating
- sweating
- If you stop taking this medication suddenly, you may experience some withdrawal effects.
- Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs to avoid while undergoing treatment
- Do not take this medication if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.
- Many drugs can increase drowsiness:
- antihistamines such as brompheniramine (Dimetane, Bromfed, others), chlorpheniramine (Chlor-Trimeton, Teldrin, others), azatadine (Optimine), clemastine (Tavist), and many others
- narcotics (pain killers) such as meperidine (Demerol), morphine (MS Contin, MSIR, others), propoxyphene (Darvon, Darvocet), hydrocodone (Lorcet, Vicodin), oxycodone (Percocet, Percodan), fentanyl (Duragesic), and codeine (Fiorinal, Fioricet, Tylenol #3, others)
- sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal), and secobarbital (Seconal)
- phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), and trifluoperazine (Stelazine)
- antidepressants such as doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), phenelzine (Nardil), and tranylcypromine (Parnate)
- Do not take any of the drugs listed above without the approval of your doctor.
- The stomach medicine cimetidine (Tagamet, Tagamet HB) and pain relievers such as aspirin, ibuprofen (Motrin, Advil), indomethacin (Indocin), ketoprofen (Orudis, Orudis KT, Oruvail), fenoprofen (Nalfon), flurbiprofen (Ansaid), naproxen (Aleve, Anaprox, Naprosyn), and nabumetone (Relafen) may all increase the pain-relieving effects of cyclobenzaprine. Use these drugs under the supervision of your doctor.
- Drugs other than those listed here may also interact. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

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