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Home >> RX Products >> Avandamet (Rosiglitazone/Metformin)

Avandamet

Generic Name: metformin and rosiglitazone (met FORE min and rose ih GLIH ta zone)
Brand Names: Avandamet

Avandamet : Important Information

  • A small number of people who have taken metformin (with and without rosiglitazone), have developed a serious condition called lactic acidosis that has been fatal in up to 50% of cases. Lactic acidosis has occurred most often in people whose kidneys were not working properly. Liver problems may also increase the risk of developing lactic acidosis. Stop taking metformin and rosiglitazone and call your doctor immediately if you experience a feeling of general discomfort or sickness; weakness; sore or aching muscles; trouble breathing, unusual drowsiness, dizziness or lightheadedness; unusual or unexplained stomach upset (after the initial stomach upset that may occur at the start of therapy with metformin and rosiglitazone); or the sudden development of a slow or irregular heartbeat. These may be signs of lactic acidosis.
  • Notify your doctor immediately if you experience an unusually rapid increase in weight or edema (water retention), shortness of breath, or chest pain during treatment with metformin rosiglitazone. These may be early symptoms of heart problems.
  • Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, or dark urine. These symptoms may be early signs of liver problems.
  • Avoid excessive alcohol intake while taking metformin and rosiglitazone. Together, alcohol and metformin and rosiglitazone may increase the risk of lactic acidosis and hypoglycemia.
  • Metformin and rosiglitazone does not usually cause hypoglycemia (low blood sugar). Nevertheless, hypoglycemia may occur, as a result of skipped meals, excessive exercise, or alcohol consumption. Know the signs and symptoms of low blood sugar, which include hunger, headache, drowsiness, weakness, dizziness, a fast heartbeat, sweating, tremor, and nausea. Carry a non-dietetic candy or glucose tablets to treat episodes of low blood sugar.

What is Avandamet

  • Metformin is used to regulate blood glucose (sugar) levels. Metformin works in three ways: first, it reduces the amount of glucose produced by the liver; second, it reduces the amount of glucose absorbed from food through the stomach; and third, it makes the insulin that the body produces work better to reduce the amount of glucose already in the blood.
  • Rosiglitazone is an antihyperglycemic agent. It helps the body respond better to insulin and it reduces the amount of sugar produced by the liver. It can help control blood sugar levels.
  • Metformin and rosiglitazone are used together in the treatment of type 2 diabetes.

What to Discuss before Using

  • Do not take metformin and rosiglitazone without first talking to your doctor if you:
    • have type 1 diabetes
    • have liver or kidney disease
    • have acute or chronic metabolic acidosis, including diabetic ketoacidosis
    • have congestive heart failure
    • have had a heart attack or a stroke
    • have a serious infection, illness, or injury
    • need to have surgery
    • need to have x-rays or other procedures using injectable contrast agents
    • are dehydrated (have lost water from your body) due to diarrhea, vomiting, fever, heat stroke, decreased fluid intake, or any other cause
    • have edema (water retention or swelling)
    • drink alcohol
    • are 80 years of age or older and have not had your kidney function tested
  • You may not be able to take metformin and rosiglitazone, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
  • Treatment with metformin and rosiglitazone may cause resumption of fertility by allowing the return of ovulation (production of eggs) in certain women with insulin resistance who were not ovulating before treatment with metformin and rosiglitazone. Talk to your doctor about adequate forms of birth control while taking metformin and rosiglitazone if birth control is desired.
  • Contact your doctor if you develop a fever or an infection, require surgery, or if you experience a serious injury. Illness or injury may cause a loss of blood sugar control and insulin (or an adjustment of a current insulin dose) may be required for a period of time.
  • Metformin and rosiglitazone is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Generally, insulin is the drug of choice for controlling diabetes during pregnancy. Do not take metformin and rosiglitazone without first talking to your doctor if you are pregnant or could become pregnant during treatment.
  • It is not known whether metformin and rosiglitazone passes into breast milk. Do not take metformin and rosiglitazone without first talking to your doctor if you are breast-feeding a baby.
  • If you are over the age of 65 years, there may be an slight increase in the risk of developing lactic acidosis due to a natural decline in kidney function with advancing age. A lower dose or special monitoring may be necessary during treatment.

Avandamet Dosage Method

  • Take exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain the instructions to you.
  • Take each dose with a full glass of water.
  • Take with meals to reduce nausea, diarrhea, and upset stomach that may occur with metformin and rosiglitazone therapy. These symptoms may be more likely to occur during the first few weeks of therapy.
  • It is important to take metformin and rosiglitazone regularly to get the most benefit.
  • A decrease in vitamin B12 may also occur during metformin and rosiglitazone therapy. Your doctor may want to monitor blood levels of vitamin B12 and you may need to take a B12 supplement. A vitamin B12 deficiency may rarely cause anemia.
  • Your doctor may want to monitor your blood sugar control and other factors with blood tests during treatment.
  • Usually, liver function is monitored with blood tests at the start of treatment, every two months for the first year of treatment, and periodically thereafter during treatment with rosiglitazone. Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, or dark urine. These symptoms may be early signs of liver problems.
  • Store at room temperature away from moisture and heat.

Miss a dose: Problems?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose.

Avandamet Overdose?

  • Seek emergency medical attention if an overdose is suspected.
  • An overdose is likely to cause lactic acidosis. Symptoms of lactic acidosis include a feeling of general discomfort or sickness; weakness; sore or aching muscles; trouble breathing; unusual drowsiness, dizziness or lightheadedness; unusual or unexplained stomach upset (after the initial stomach upset that may occur at the start of therapy with metformin and rosiglitazone); and the sudden development of a slow or irregular heartbeat.

Avoid During Treatment

  • Some conditions may increase the risk of developing lactic acidosis while taking metformin and rosiglitazone. Tell your doctor that you are taking metformin and rosiglitazone if you become ill; if you have a heart attack; have a stroke; develop congestive heart failure; experience diarrhea, vomiting, fever, or dehydration from any cause; decrease the amount of food or liquid in your normal diet, or develop other health conditions. You may need to stop treatment with metformin and rosiglitazone for a short amount of time until you are feeling better.
  • Avoid excessive alcohol intake while taking metformin and rosiglitazone. Together, alcohol and metformin and rosiglitazone may increase the risk of lactic acidosis and hypoglycemia.
  • Follow diet, medication, and exercise routines very closely. Changing any of these things can affect blood sugar levels.
  • Tell your doctor or other health care provider that you are taking this medication if you need to have surgery or x-ray procedures that require injection of contrast agents. Treatment with metformin and rosiglitazone may need to be stopped for a short period of time.

Avandamet Side Effects

  • Stop taking this medication and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).
  • Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, or dark urine. These symptoms may be early signs of liver problems.
  • Notify your doctor immediately if you experience an unusually rapid increase in weight or edema (water retention), shortness of breath, or chest pain during treatment with metformin rosiglitazone. These may be early symptoms of heart problems.
  • A small number of people who have taken metformin (with and without rosiglitazone), have developed a serious condition called lactic acidosis that has been fatal in up to 50% of cases. Lactic acidosis has occurred most often in people whose kidneys were not working properly. Liver problems may also increase the risk of developing lactic acidosis. Stop taking metformin and rosiglitazone and call your doctor immediately if you experience a feeling of general discomfort or sickness; weakness; sore or aching muscles; trouble breathing, unusual drowsiness, dizziness or lightheadedness; unusual or unexplained stomach upset (after the initial stomach upset that may occur at the start of therapy with metformin and rosiglitazone); or the sudden development of a slow or irregular heartbeat. These may be signs of lactic acidosis.
  • Metformin and rosiglitazone does not usually cause hypoglycemia (low blood sugar). Nevertheless, hypoglycemia may occur, as a result of skipped meals, excessive exercise, or alcohol consumption. Know the signs and symptoms of low blood sugar, which include hunger, headache, drowsiness, weakness, dizziness, a fast heartbeat, sweating, tremor, and nausea. Carry a non-dietetic candy or glucose tablets to treat episodes of low blood sugar.
  • Other, less serious side effects may be more likely to occur. Continue to take this medication and talk to your doctor if you experience:
    • nausea, vomiting, abdominal pain, or diarrhea at the start of therapy
    • abdominal bloating or increased gas production
    • decreased appetite or changes in taste (metallic taste in the mouth)
    • cold-like symptoms (may indicate an upper respiratory tract infection)
    • weight gain
    • fatigue
    • headache
  • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

  • Do not take any over-the-counter cough, cold, allergy, pain, or weight loss medications without first talking to your doctor.
  • Many drugs may interact with metformin and rosiglitazone or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

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Avandamet tablets contain two active ingredients, rosiglitazone maleate and metformin hydrochloride. These are both medicines that are used to help control blood sugar levels in people with type 2 or non-insulin dependent diabetes (NIDDM). Avandamet drug if taken along with diet and exercise helps to improve blood sugar control. Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by increasing insulin sensitivity.

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Avandamet drug has various side effects like weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting. Avandamet medication for diabetes should be started after consulting a doctor. Learn more about avandamet drug usage, avandamet drug dosage method and overdose problems.

 

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