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Wellbutrin, Zyban

Generic Name: bupropion (oral) (byoo PROE pee on)
Brand Names: Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban SR

Wellbutrin: Important Information

• While you are taking this medication you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts especially at the start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/ or physical hyperactivity). These symptoms may be associated with development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment. Do not stop taking medication without first talking to your healthcare provider.
• Do not stop taking medication without first talking to your doctor. It may be several weeks before you begin to feel better, and you may require continuous treatment for quite some time.
• Avoid alcohol or drink it only in moderation. Alcohol may increase the risk of having a seizure while taking this medication. However, if you usually drink a lot of alcohol, talk with your doctor before stopping. Suddenly stopping may increase the risk of having a seizure. Talk to your doctor about alcohol use before starting treatment.
• Do not crush, chew, or break the sustained- or extended-release tablets (Wellbutrin SR, Wellbutrin XL, Zyban SR). Swallow them whole. They are specially formulated to release slowly in the body. If you are unsure of the formulation of your medication, ask your healthcare provider.
• May be used to treat different medical conditions. You should not be taking more than one product containing bupropion at a time (e.g., Wellbutrin and Zyban SR). Talk to your doctor if a second product is prescribed for you. Too much of this medicine can increase the risk of a seizure.
• Never take more medicine in one dose or in one day than is directed by your doctor. Higher doses may increase the risk of a seizure.

What is Wellbutrin

• An antidepressant medication. The exact way that this medication works is unknown.
• Used to relieve symptoms of depression such as feelings of sadness, worthlessness or guilt, loss of interest in daily activities, changes in appetite, tiredness, sleeping too much, insomnia, and thoughts of death or suicide. Also used to help people stop smoking by reducing withdrawal effects.

What to Discuss before Using

• While you are taking this medication you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts especially at the start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/ or physical hyperactivity). These symptoms may be associated with development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment. Do not stop taking without first talking to your healthcare provider.
• Do not take if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.
• Do not take without first talk to your doctor if you:
  • have liver problems
  • have kidney problems;
  • have heart problems, high blood pressure, or history of heart attack;
  • have anorexia or bulimia;
  • have epilepsy or a seizure disorder;
  • have a head injury or brain or spinal column tumor;
  • have diabetes
  • drink alcohol, use street drugs, or take a prescription benzodiazepine such as alprazolam (Xanax), diazepam (Valium), temazepam (Restoril), and others.
• You may not be able to take this medication or you may require a special dosage or monitoring during treatment.
• May be used to treat different medical conditions. You should not be taking more than one product containing bupropion at a time (e.g., Wellbutrin and Zyban). Talk to your doctor if a second product is prescribed for you. Too much of this medicine can increase the risk of a seizure.
• In the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take without first talking to your doctor if you are pregnant or could become pregnant during treatment.
• It is not known whether this medication will be harmful to a nursing baby. Do not take without first talking to your doctor if you are breast-feeding a baby.

Wellbutrin Dosage Method

• Take exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
• Take each dose with a full glass of water.
• Can be taken with or without food.
• Do not crush, chew, or break the sustained- or extended-release tablets (Wellbutrin SR, Wellbutrin XL and Zyban SR). Swallow them whole. They are specially formulated to release slowly in the body. If you are unsure of the formulation of your medication, ask your healthcare provider.
• Never take more medication in one dose or in one day than is directed by your doctor. Higher doses may increase the risk of a seizure. Maximum doses are as follows:
  • No single dose of the regular-release product should be more than 150 mg, and doses should be taken at least 6 hours apart with a maximum daily dose of 450 mg.
  • Single doses of the sustained-release product should not exceed 200 mg and should be taken at least 8 hours apart with a maximum daily dose of 400 mg.
  • Single doses of the extended-release product should not exceed 450 mg, and doses should be taken 24 hours apart.
  • Single doses of Zyban SR should not exceed 150 mg and doses should be taken at least 8 hours apart with a maximum daily dose of 300 mg.
• If you are taking Zyban SR to help you stop smoking, a target "quit date" is usually set for the second week of treatment with Zyban SR. Although it is not physically harmful to smoke while taking Zyban SR, continuing to smoke after the date you set to stop smoking will seriously reduce your chance of breaking the smoking habit.
• Nicotine replacement products (patches or gum) can be used during treatment with Zyban SR under the supervision of a doctor. Zyban SR and a nicotine replacement product together may raise blood pressure and your doctor may want to check your blood pressure regularly. Do not smoke at any time if you are using a nicotine product along with Zyban SR as this can cause serious side effects from too much nicotine.
• The WELLBUTRIN XL tablet is covered by a shell that slowly releases the medicine inside the body. You may notice something in the stool that looks like a tablet. This is normal. This is the empty shell passing from the body.
• It is important to take regularly to get the most benefit.
• Do not stop taking without first talking to your doctor. It may be several weeks before you begin to feel better, and you may require continuous treatment for quite some time.
• Your doctor may want you to have blood tests or other medical evaluations during treatment to monitor progress and side effects.
• Tablets may have an odor. If present, this odor is normal.
• Store at room temperature away from moisture and heat

Miss a dose: Problems?

Skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose.

Wellbutrin Overdose?

• Seek emergency medical attention if an overdose is suspected.
• Symptoms of an overdose include seizures, hallucinations, loss of consciousness, weakness, a fast heartbeat, and heart attack.

Avoid During Treatment

• Avoid alcohol or drink it only in moderation. Alcohol may increase the risk of having a seizure while taking bupropion. However, if you usually drink a lot of alcohol, talk with your doctor before stopping. Suddenly stopping may increase the risk of having a seizure. Talk to your doctor about alcohol use before starting treatment.
• Use caution when driving, operating machinery, or performing other hazardous activities. May cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
• Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.
• May be used to treat different medical conditions. You should not be taking more than one product containing bupropion at a time (e.g., Wellbutrin and Zyban SR). Talk to your doctor if a second product is prescribed for you. Too much of this medicine can increase the risk of a seizure.

Wellbutrin Side effects

• If you experience any of the following uncommon but serious side effects, stop taking this medication and seek emergency medical attention or contact your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
  • seizures
  • fast or irregular heartbeats
• Other, less serious side effects may be more likely to occur. Continue to take medication and talk to your doctor if you experience:
  • headache
  • insomnia
  • dry mouth
  • tremors, restlessness, agitation, or anxiety
  • dizziness or drowsiness
  • sweating
  • skin rash
  • ringing in the ears
  • flulike symptoms such as aching muscles, fatigue, and discomfort
  • frequent urination
  • weight loss or gain
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs to avoid while undergoing treatment

• Do not take this medication if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.
• Many drugs can interact, resulting in side effects and/ or decreased effectiveness of the medication. Do not take any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, without first talking to your doctor during treatment.

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Wellbutrin medicine comes as tablet to be taken orally and cannot be split. Wellbutrin (Bupropion) is available in 3 different dosage forms; a regular tablet called Wellbutrin (Bupropion), a sustained-release tablet called Wellbutrin SR and an extended-release tablet called Wellbutrin XL. Store Wellbutrin (Bupropion) at room temperature away from light and moisture. Be sure to consult your doctor or pharmacist before taking Wellbutrin (Bupropion).

Wellbutrin (Bupropion), Wellbutril SR and Wellbutrin XL may be used to treat attention-deficit hyperactivity disorder. Wellbutrin medication is used to treat depression. Wellbutrin (Bupropion) can improve your mood and feelings of well-being. It works by helping to restore the balance of natural chemicals (neurotransmitters) in the brain. Wellbutrin (Bupropion) is a relatively new antidepressant medication. Wellbutrin (Bupropion) is also used to help people quit smoking by decreasing cravings and nicotine withdrawal effects.